The museum contains 44 collections donated to the Romanian State beginning with 1927 by the families of: Hurmuz Aznavorian, Dumitru and Maria Ştefănescu, Josefina, and Eugen Taru, Emanoil Romulus Anca and Ortansa Dinulescu Anca, Garabet Avakian, Mircea Petrescu and Artemiza Petrescu, Sandu Lieblich, Sică Alexandrescu, Clara and Anatol E. Baconsky, Sorin Schächter, Céline Emilian, Marcu Beza – Hortensia and Vasile Beza, Alexandra and Barbu Slătineanu, Béatrice and Hrandt Avakian.
The museum lapidarium hosts stone carved items of old Romanian art, among which a few pieces extracted from Văcărești Monastery, demolished in 1986 at Nicolae Ceaușescu's order.
The Romanian writer Ion Ghica (1816-1897) wrote about the luxurious interior in his memoir: "... the walls of all the chambers stuccoed, imitating the rarest and most beautiful marble, the ceilings of a rare wealth and taste...
The chambers all winter bedding with rich carpets from Usack and Agem and in summer with fine mats from India; coverings and thick silk curtains from Damascus and Aleppo.
"[3] After Romanit died in 1834, the building was rented 1834-1842 by Prince (domnitor) Alexandru II Ghica, who established a chancery there, where people could come to register complaints.