The museum has ten exhibition rooms and an archaeological theme of the history of the Comayagua Valley from ancient times to the present day.

[1] The property was built at the end of the 16th century as the private home of Francisco del Barco y Santiponce, the Spanish conqueror of San Jorge de Olancho.

In the 18th century, the house became the property of Joaquín Fernández Lindo y Molina, councilor of the Comayagua City Council.

His son, Juan Lindo, was a royal second lieutenant of the city and political chief and mayor of the province of Comayagua, then a deputy in the National Constituent Assembly and finally president of Honduras.

In 1804, the house was inhabited by the then dean of the Guatemalan Bar Association, Norberto Serrano Polo, legal advisor to the Comayagua Municipality.