[2][3][6][7] The Museum of Regional History narrates the history of the region, from its indigenous Caddo people and early Spanish and French explorers, to its agriculture and early industry, to its relationship to railroads, World War II, and the civil rights movement.

[2][7][8] Its Caddo collections include jewelry, pottery, and tools as well as rare images.

[9] Its most prominent collection documents the region's musical history, which includes Scott Joplin (widely recognized as the "Father of Ragtime"), Huddie "Leadbelly" Ledbetter, and Conlon Nancarrow.

[9] The archives also includes the Texarkana city directory collection and Pioneer History files.

[10] Media related to Museum of Regional History (Texarkana, Texas) at Wikimedia Commons