[3][4] With the fall of the Western Roman Empire and the subsequent Barbarian invasions, the flatlands were gradually abandoned as the inhabitants sought refuge in the hilly area which was more easily defended.

In 1149, the Bishop of Belluno conferred the fief of Mussolente on Ezzelino I da Romano, and it remained in control of the Ezzelini family until their fall in 1260.

In the early 14th century Mussolente's allegiance to the Scaligeri family made it a target of militias from other cities in the region who attacked and burnt down much of the town in 1320.

Lorenzo Busnardo (1532–1598), described in the Inquisition documents as a "vagabond priest" from Mussolente, was accused of using chess games to lure people into seditious religious conversations.

The years following the end of the Second World War saw prosperity gradually return to the town, with further agricultural development, and the establishment of factories and small businesses.

After decades of decay, it was bought in 1900 by Giulio Drigo who restored the building and its surrounding park (considered one of the finest in the Veneto region).

The church's bell tower is separate from the main building, and at its base stands a ruined chapel dedicated to Saint Nicholas.