[4] The special agent notifies the player that the agency is onto the man from the dog case (whose name is revealed to be Morcubus) believing he has a grand villainous plan.

[5][6] The player wields several tools throughout the game which are a wrench used to salvage spare parts, a magnifying glass which is used to track footsteps and a crowbar used to pry objects open.

These cases take them through a variety of new regions including a mountain range, an industrial district, a bayou mansion, a beachside boardwalk and finally an Aztec-themed temple.

[19][20] In Japan, where the game was ported for release under the name Boku to Sim no Machi Agents: Mai no Kaitō Kara Hihō wo ma mo re Taisaku Ikusa!

[6] However, GameSpot's Allen Rausch felt that "Your sidekick Buddy, for example, provides most of the laugh-out loud humor through his wonderfully expressive body language."

[31] Heath Hooker of GameZone commended the graphics, storyline and dialogue, noted that MySims Agents would be "well received by the Wii's younger audience", and considered that certain hints were unclear while some missions were "extremely simple".

[32] Writing for The Independent, Rebecca Armstrong declared that the game is "[an] acute twist on both the Sims and James Bond" and that it is a "charming new addition to the family".

[9] Dharn Ubarry of Jeuxvideo.com opined that it "leaves much to be desired" and does not "break three feet of a duck", considered the minigames to be "simplistic" and "soporific" and was also critical of the day-night cycle.

[10] Gamekult's Loup Lassinat-Foubert stated that the progression of the game "isn't much more exciting", regarded the minigames to "not [be] executed properly" and pointed out its graphical and technical bugs.