The site's critical consensus reads, "My Blind Brother takes a refreshingly character-driven approach to its familiar sibling rivalry while adding a somewhat unexpected twist.

[8] Andrew Barker of Variety gave the film a positive review, writing that the film "takes an ostensibly dark premise — a man of few qualities attempts to steal his overachieving blind brother’s girlfriend — and turns it into a featherweight frolic as winningly unambitious as its central couple played by Nick Kroll and Jenny Slate.

[10] In a review for The Seattle Times, Tom Keogh praised the film's "love-hate energy", especially when it comes to "Robbie's condescension [and] Bill's passive-aggressiveness".

[11] Dmitry Samarov of Chicago Reader wrote "Zoe Kazan provides the only compelling moments... yet playing the normal one among such a group of narcissists is a thankless task".

His response was "Though My Blind Brother clearly isn't aiming for the feel-good realm, the emotions never ring true enough to make any of the purposely flawed leads relatable, never mind likable".