They were the winners of the Asayan audition (similar to the American Idol series) in 2000 organized by Sony Music Entertainment Japan.

Their #1 streak was broken by the KinKi Kids' album H Album: Hand, scoring them a #2 rank for Fo(u)r. Chemistry is also known in Korea for the popular collaboration song "Let's Get Together Now," featuring talents from both Korea and Japan and for collaborating with Korean singer Lena Park who appears in the B-side "Dance with Me" on the "Kimi ga Iru" single.

Their 15th single "Wings of Words" was used as the fourth opening theme for Mobile Suit Gundam SEED Destiny from PHASE-38 to 49.

Chemistry performed this song live in collaboration with the two-time Olympic champion in figure skating, Yuzuru Hanyu, at the 2018 Fantasy on Ice in Makuhari and Kanazawa.

[5] After going on hiatus in 2012 so that both members could focus on pursuing solo careers, the pair resumed activities as a musical duo in 2017.