A second version was released as a single on the Bizarre and Reprise labels as "My Guitar."

The single version of the song, recorded in June 1969 at A & R Recording Studios in New York City, differs from the album version, includes a longer break before the second verse is reprised, and is roughly half a minute longer.

A shorter edit of the single version has been released on You Can't Do That on Stage Anymore, Vol.

[2] His son Dweezil Zappa's 1988 solo album is named after the song and contains a cover of it, both as a tribute to his father.

"The Central Scrutinizer," the spoken-word track that opens Act I of Joe's Garage, began as an updated version of "My Guitar Wants to Kill Your Mama."