My Wife's Best Friend is a 1952 American comedy film directed by Richard Sale, starring Anne Baxter and Macdonald Carey, with Catherine McLeod in the titular role.

Virginia Mason (Anne Baxter) and George (Macdonald Carey), husband and wife from Mellford, Illinois, are on an airliner for their second honeymoon in Hawaii.

Certain that he's facing an imminent demise, George confesses to Virginia that he's had an affair with her best friend Jane Richards (Catherine McLeod).

Virginia mulls over several potential revenges in her mind, casting herself as various famous women of history.

The plane lands safely, at which time Virginia learns that the "affair" was nothing more than a discreet flirtation.