It is often found as a commensal in the respiratory tract of pigs, and rarely in the skin of humans.

M. hyorhinis can prevent cell death caused by nicotinamide phosphoribosyltransferase inhibitors.

There is some evidence implicating M. hyorhinis in the pathogenesis of scleroderma, a chronic systemic disease of humans.

[2] Another study found that injecting M. hyorhinis into mice induces a scleroderma-like autoimmune disease.

[3] However, more research is needed to confirm or refute the link between M. hyorhinis and scleroderma.