That same year, Myersville was connected to its neighboring town Hagerstown by the blue ridge trolley.

On January 4, 1919, a large fire destroyed many shops and buildings in the center of town.

In 1968 Insterstate 70 was extended through Myersville in 1981 the town boundaries were expanded for the first time[4] The Peter of P. Grossnickel Farm was listed on the National Register of Historic Places in 1998.

[5] In October 2002, the Washington, D.C. metropolitan area snipers John Allen Muhammad and Lee Boyd Malvo who terrorized the region were apprehended at a rest stop along westbound I-70 in Myersville.

According to the United States Census Bureau, the town has a total area of 1.02 square miles (2.64 km2), all land.

[6] The Myersville area is the source of Catoctin Creek, which roughly flows in a "C" loop pattern (northside to eastside to southside) just outside the city limits.

The main highway that serves the town is Interstate 70, which heads eastward from Myersville to Baltimore and westward to Pittsburgh.

U.S. Route 40 passes just to the northeast of the town limits and provides an alternative to I-70 for east–west travelers.