Mylopotamos (Greek: Μυλοπόταμος) is a municipality in Rethymno regional unit, on Crete, southern Greece.

[2] The municipal unit has an area of 360.703 km2 (139.268 sq mi).

[3] The municipality Mylopotamos was formed at the 2011 local government reform by the merger of the following 3 former municipalities, which became municipal units:[2] The province of Mylopotamos (Greek: Επαρχία Μυλοποτάμου) was one of the provinces of Rethymno Prefecture.

Its territory corresponded with that of the current municipalities Mylopotamos and Anogeia.

Modern Lefterna was the seat since 1212 of a Latin Roman Catholic Diocese of Milopotamus, which was suppressed in 1669 and turned into a Latin Titular bishopric of lowest (episcopal), which had its name changed in the 20th century into titular see of Eleutherna.