The name is Norwegian for python, a term which in Scandinavia also has gained a slang adjective meaning of "disgusting" or "sick".

The magazine also adopted a python snake as mascot (after discarding their original polar bear), who occasionally featured in his own comics.

Some of Pyton's most prominent artists were Tommy Sydsæter, Bjørn Ousland, Arild Midthun (pen name: Arnold Milten), Kristian B. Walters and Frode Øverli who a few years later created the successful and popular comic strip Pondus.

Apart from publishing older Norwegian material, this spinoff edition also showcased Swedish artists such as Joakim Lindengren, Mikael Grahn and Alf Woxnerud etc.

In 1992, the Swedish spinoff Mega-Pyton appeared, in the beginning it was mostly a thicker version of the original magazine, but after a while it evolved into a more alternative/underground-oriented magazine featuring artists such as Ivan Brunetti, Mike Diana and Sam Henderson, as well as local Swedish artists including David Liljemark.

Regular strips in Myrkky included Myyntimies Mynttinen, Pera Pervo (Pervo-Kris) and Firkin the Cat.