Myrsini lies in a flat coastal plain that stretches from Amaliada to Kato Achaia.

During the Byzantine Empire, a village named Agios Nikolaos (St Nicholas) was located in the area.

In the 16th century, the inhabitants moved further inland to escape corsair raids and founded the present village.

Along with the rest of the Peloponnese, the village was conquered in 1685 by the Republic of Venice during the Morean War, but was recovered by the Ottomans in 1715.

It became a part of Greece after the Greek War of Independence, and was renamed to its present name in 1915. Notable residents of Myrsini include: