[3] A superhero anthology with no regular starring feature, Mystic Comics introduced at least three notable characters: the Blazing Skull (issue #5, March 1941), who made appearances both in the Golden Age and in the 2000s;[4][5] and the Destroyer (issue #6, Oct. 1941),[6] noted by comics historian and former Marvel editor-in-chief Roy Thomas as "Stan's most popular superhero creation before the Fantastic Four".

An antihero who killed evildoers to deliver their souls to Satan, her master, she is unrelated to Marvel Comics' later superspy character, Black Widow.

Additional superheroes introduced in this initial series include the Thin Man, by artist Klaus Nordling and an unknown writer (issue #4, Aug. 1940); the Blue Blaze, a living dead man who disappeared into a swamp in his final appearance, by Harry Douglas who signed his name "Harry / Douglas" leading to much confusion and many theories over the possibility of two creators.

[12] Titled simply Mystic and published by Marvel's 1950s iteration, Atlas Comics, this was a 61-issue horror-suspense anthology (March 1951-Aug. 1957).

Mystic debuted shortly before Atlas' Strange Tales, increasing the company's science fiction/fantasy/horror line from four titles to six.