Myx Awards 2021 is the 16th installment of the Myx Music Awards, acknowledging the biggest hit makers of 2020 in the Philippine music industry.

The awards were held virtually for the second time (since 2020) due to the ongoing coronavirus pandemic.

Nominees were announced on June 19, 2021 through the music channel's digital accounts on Kumu, Twitter, Facebook, TikTok, and YouTube livestream.

[2] For the tenth consecutive year, fans are voting online through the Myx website.

[4] Winners are listed first and highlighted in boldface.