2PFR1017960ENSG00000156006ENSMUSG00000025588P11245P50294NM_000015NM_008673NP_000006NP_032699N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.

The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens.

Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes.

Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity.

[6] The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).