The series tells the story of a fictional spy agency and its agents—children who have their "nerdy" characteristics upgraded into a tool that they can use to fight crime.

As of 2022, an animated show based on the series is in development with Lisa Zusmer DelPrete, DelZus Productions LLC.

The book series centers around National Espionage, Rescue, and Defense Society, or N.E.R.D.S., a spy agency that contains children with considerably "nerdy" upgrades.

Dr. Jigsaw and Simon or Heathcliff "Choppers" hatches a plot to change the surface of the earth.

Things get more complicated when the team are stripped of their powers and have to rely on their resources to save the day.