[5] Since 2018, Coles has served as chair of the board of directors for Cerevel Therapeutics, a company focused on neurological disease treatment.
[12] Coles has served as chair and CEO of TRATE Enterprises, a privately held real estate management and ventures company, since 2013.
[13] In October 2014, Coles co-founded (with researcher Susan Lindquist) and served as chair and CEO of Yumanity Therapeutics, a biopharmaceutical company specializing in Alzheimer's and Parkinson's diseases.
[10][12][1] In 2005, Coles joined NPS Pharmaceuticals, Inc. as company COO and president, and in 2006, was named chief executive officer.
Their oldest son was diagnosed with non-Hodgkin's lymphoma, at the age of 12, and underwent a bone marrow transplant protocol at Memorial Sloan Kettering.