The N5 is a national route in South Africa that connects the N1 at Winburg with the N3 at Harrismith, via Senekal, Paul Roux and Bethlehem.

It is initially co-signed with the R708 eastwards, bypassing Winburg to the north (where the R709 provides access to the town centre).

In the Bethlehem City Centre, the N5 meets the R26 and the south-eastern terminus of the R76 at the Commissioner Street junction.

From Kestell, the N5 heads eastwards for 41 kilometres to meet the north-western terminus of the R74 and enter the city of Harrismith.

Just south of the Harrismith City Centre, the N5 crosses the Wilge River and reaches its eastern terminus at an interchange with the N3.