Major towns and cities along the route of the N6 include Accra, Amasaman, Nsawam, Suhum, Apedwa, Bunso, Nkawkaw, Juaso, Konongo, Bomfa, Ejisu, Kumasi.

The N6 begins at the Nasawam Road at the intersection with the N1 in Accra and travels north through Ofankor and Pokuase before entering the Eastern Region.

The route continues north intersecting with the R41 at Suhum and the R60 at Apedwa before joining the N4 at Bunso.

The N6 runs west through Breku to Juaso, where it intersects with the IR2 and continues to Konongo.

The route runs near the Kwame Nkrumah University of Science and Technology campus before entering the city of Kumasi, where it intersects with the N10, IR4, IR5, R108, and R52.