NASA Headquarters is organized into four Mission Directorates: Aeronautics, Exploration Systems, Science, and Space Operations.

Ten field centers and a variety of installations around the country conduct the day-to-day work of the agency.

[5] It is currently owned by South Korean investment firm Hana Asset Management and leased to NASA through 2028.

[1] On June 12, 2019, the street in front of the building was given the honorary name of Hidden Figures Way in honor of some of NASA's black women mathematicians, Katherine Johnson, Dorothy Vaughan, and Mary W. Jackson, who were the central characters in the 2016 film Hidden Figures.

The Earth Information Center exhibit shows how the agency views Earth from space, tracking patterns in air temperature and quality, climate, water levels, and ecosystems and how that can help humans understand and fight climate change.