[4][5][6] The protein encoded by this gene is localized exclusively in the cell nucleus.

It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres.

It also plays an important role in stress fiber formation.

Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.

[6] NCKIPSD has been shown to interact with Grb2[7][8] and NCK1.