[5] Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors.

Autism is characterized by a wide range of social and cognitive deficits, which are partially attributed to faulty synaptic communication between neurons.

[7] These alpha neurexins are involved in communication through coupling mechanisms of calcium channels and vesicle exocytosis, to ensure that neurotransmitters are properly released.

These mice showed impaired social functioning, decreased motor response in new situations, and increased aggressive behavior in males.

The gene is 1,112,187 bases in length, is located on the Crick (minus) strand and encodes a protein of 1,477 amino acids (molecular weight 161.883 kDa).