[2] The school offers an accelerated mathematics and science curriculum integrated with language, arts, humanities, and sports, in a modular system.

The curriculum in these honours courses usually covers university material, such as linear algebra in mathematics, calculus-based electromagnetism in physics, organic synthesis and spectroscopy in chemistry, and proteomics in biology.

To graduate with the NUS High School diploma, students must major in mathematics and at least two science subjects (including computer studies).

Students are also encouraged to take Advanced Placement and SAT examinations in their senior years for credits for admission into foreign universities, though these are not necessary for graduation.

NUS High School offers various sports to choose from as part of its options for co-curricular activities.

The four houses, named Faraday, Fibonacci, Fleming and Nobel, bear the colours yellow, red, blue and green respectively.

[6] Currently, the NUS High School campus sits on 4.7 hectares of land off Clementi Ave 1.

The school moved operations from its temporary campus at the former Raffles Junior College grounds at Mount Sinai Road in 2005.

These include, but are not limited to, a drawing of the four DNA bases (ACGT) on the roof of the concourse, a timeline of major mathematical discoveries, and coloured metal shades to represent the digits of pi.