The event took place on Sunday, September 1, 2024, at the Ball Arena in Denver, Colorado and aired via WWE's livestreaming platforms.

In the main event, which was an interpromotional match, Ethan Page defeated TNA wrestler Joe Hendry to retain the NXT Championship.

No Mercy was first held by the American professional wrestling promotion WWE as a United Kingdom-exclusive pay-per-view (PPV) event in May 1999.

[3] No Mercy was discontinued in 2009, but it was reinstated in October 2016 following the reintroduction of the brand extension, which brought back brand-exclusive PPVs.

[6] On July 9, 2024, it was reported that the second No Mercy under the NXT banner, and 15th overall, would be held on September 1, 2024, in Denver, Colorado at the Ball Arena.

[10][11] On the August 13 episode of NXT, the brand's General Manager Ava announced that on the next episode, a No Mercy six-woman Gauntlet Eliminator would be held featuring various women who had never previously challenged for the NXT Women's Championship, with the winner facing Roxanne Perez for the championship at No Mercy.

Wren Sinclair, Adriana Rizzo, Sol Ruca, Jaida Parker, Kendal Grey, and Brinley Reece were announced as the six competitors.

On the August 13 episode of NXT, D'Angelo lost the Cup to No Quarter Catch Crew (NQCC) member Charlie Dempsey.

[12] The following week, Dempsey and his stablemates Myles Borne and Wren Sinclair celebrated his victory, but were interrupted by Femi, who stated his interest in winning the Cup.

[13] At NXT: The Great American Bash Night 2, Wes Lee attacked fellow Rascalz members Trey Miguel and Zachary Wentz from TNA after he and Wentz failed to win the NXT Tag Team Championship, turning heel for the first time in his career.

Following the series premiere on The CW, all future NXT events began to carry the WWE logo starting with Halloween Havoc.