Besides the sanctuary the establishment also runs a carnivore conservation research programme, the Clever Cubs pre-primary school, and a clinic for the San people.
In January 2011, Brad Pitt and Angelina Jolie chose Naankuse to become a partner of the Shiloh Jolie-Pitt Foundation, in honour of their Namibian-born daughter.
Captured cats are fitted with a radio collar before being released back into the wild allowing Naankuse to track their movements, check on their condition and gain a better understanding of their ecology for future conservation.
The project also works to relocate proven problem animals (those that prey on farmers' cattle) to safer conservation areas and reduce the number needlessly shot or killed.
N/'an ku sê has been repeatedly investigated by the Namibian Ministry of Environment, Forestry and Tourism for permit violations and illegal breeding and translocating of wild animals, particularly cheetahs and elephants.