After graduating from the Imperial Medical and Surgical Academy, she worked as a doctor in Novgorod and Saratov, as well as in Kherson during the Russo-Turkish War.

During the late 1870s, Bantle began collaborating with the Narodniks, for which she was arrested and exiled to the Vologda province of the Russian North, where she became the region's first woman doctor.

[1] On 15 August 1876, Grigori Machtet directed Bantle, as well as Aleksandr Klushyn [ru] and Augustina Sinkevich, to remove any items that might compromise them from the flat of Yevgeny Bartoshevich.

[3] She was later charged with communicating with people imprisoned in Saint Petersburg's pre-trial detention centre [ru] in order to secure their release.

[2] During her time in Nikolskoye, she established an inoculation program to provide people with the smallpox vaccine, as well as a maternity ward and a nursery.

[5] In 1923, when a tuberculosis outbreak hit Vologda province, Bantle collected thousands of rubles through a medical lottery to help fight the disease.