He has acted in 143, Anji, Shock, Sri Ramadasu, Chandamama and Orange.

He has produced several films with his brothers, Chiranjeevi and Pawan Kalyan under Anjana Productions.

[3] He appeared in television serials[4] and was a judge on the comedy show, Jabardasth, which aired on ETV.

[5] Naga Babu joined Janasena Party established by his brother Pawan Kalyan and contested as a M.P.

candidate for Narasapuram Lok Sabha constituency in the 2019 Indian general election.