The club is based in the North Eastern Victorian town of Nagambie.

[2] At the club's 1888 annual meeting, it was decided to join the North Eastern Football Association.

[6] In 1912, Nagambie joined the Goulburn Valley District Football Association.

[9] In 1946, Nagambie FC rover and 1949 captain, Tommy Deane won the 1946 Stawell Gift.

[10][11] The club is known as "The Lakers" and wear red, white and black panels similar to the Saints guernsey.