He studied at the Azerbaijan State Art School in 1936–1940, but was unable to continue his higher education due to the outbreak of the Great Patriotic War.

His works of this kind include "Gubali Fatali khan" (1947), "General Hazi Aslanov" (1949), "Sara Ashurbeyli" (1951), "Poet Mirza Ali Mojuz" (1954), "Writer Abdulla Shaig" (1955)., "Mother" (1967), "Writer Jalil Mammadguluzadeh" (1967), "Poet Samad Vurgun" (1967), "Academician Mikayil Useynov" (1972), "Sattar Bahlulzade" (1973), "Uzeyir Hajibeyov" (1975), "Nasreddin Tusi" and other portraits.

[6] He expressed his attitude to the negative situations he encountered in such cartoons as "Caring Farm Manager", "This is how a real board of honor is like", "We finally found a language", "Wordless" and others.

He created portraits of a number of cultural figures, worked on friendly caricatures of Tahir Salahov, Mikayil Abdullayev, Fikret Amirov, Jalal Garyaghdi, Bashir Safaroglu and others.

[5] Najafgulu Ismayilov has participated in art exhibitions organized in the republic and Moscow since the 1940s with historical plaques, copies, as well as images of cultural figures.