[6] After the end of World War II, Spiru was elected to lead the "State Planning Commission", the highest entity in the economical sphere in Albania.

Soon he would become one of the victims of the factional war inside the Party: on one hand, the so-called "intellectuals" or "moderates" led by Mehmet Shehu and Sejfulla Malëshova and on the other hand the so-called "workers" under the leadership of Koçi Xoxe, Deputy Prime Minister and Minister of Interior, also head of the State Security Service Sigurimi.

[7][8] In April 1947, Spiru led new negotiations in Belgrade, where he asked for the conclusion of a revised trade agreement and increased economic aid.

Instead Hoxha and Spiru flew in July 1947 to Moscow and concluded a trade agreement with the Soviet Union, which guaranteed to Albania safe-ground for the refusal of the Yugoslavian support.

Spiru was married to Liri Belishova, herself a member of the Politburo of the Party of Labour of Albania who would be expelled and persecuted in 1960 for her pro-Soviet stance during the Albanian–Soviet split.