Mehta is known for his portrayal of Shivaay Singh Oberoi in Ishqbaaaz and Ram Kapoor in Bade Achhe Lagte Hain 2.

He has since starred in the series Never Kiss Your Best Friend (2020-2022), the short film Ved and Arya (2020) and Bade Achhe Lagte Hain 3 (2023).

He was also trained in dance forms including jazz, hip hop, break, folk, salsa and contemporary.

[7] In 2008, he made his Hindi film debut with Haal-e-Dil, playing a painter Shekhar opposite Amita Patak.

Taran Adarsh of Bollywood Hungama noted, "Nakuul Mehta in all fairness, is very confident, a bundle of energy and knows his job well.

[17] In 2017, he played Shivaay in Indian television's first spin-off series, Dil Boley Oberoi opposite Surbhi Chandna.

[21] In 2020, Mehta first appeared in the short film Ved and Arya alongside Sanaya Irani, playing a supportive brother.

Rahul Desai of Film Companion stated, "Nakuul Mehta doesn't overdo the urbane drawl-coolness while reacting to his sister's confessions.

"[29] In 2023, Mehta played Ram Kapoor in Bade Achhe Lagte Hain 3, a sequel to the previous seasons, opposite Disha Parmar.

[35] Adit Ganguly of Cosmopolitan India termed him "charming, classy and charismatic" and noted, "Mehta is one of the biggest names in Indian television today and is perennially expanding the scope of his art and talent.

"[36] Asjad Nazir from Eastern Eye noted Mehta's dashing "good looks" and ability to deliver a "winning performance".

[40] Apart from his acting career, he is a celebrity endorser for several brands and products such as Westside, Fair & Handsome, Karbonn Mobiles and UltraTech Cement.