The stream flows generally east-northeast, and joins the Appomattox River as a right-bank tributary at Lake Chesdin 13 miles (21 km) west of Petersburg.

The Namozine Creek basin consists mostly of forest and farmland; US 460 through Dinwiddie closely follows the southern rim of the watershed for several miles, between Blackstone and Church Road.

[2] Early spellings of the name on property records include "Nummisseen" and "Nammisseen"; numerous variants (or misspellings) more similar to the present-day version, such as "Namozain", "Namozeen", and "Namozene", arose slightly later.

Confederate soldiers entrenched at the main stream ford in earthworks that they thought to be a safe defense from the enemy were surprised by the flanking maneuver and fled in haste.

[13] As of 2022, the U.S. Environmental Protection Agency had noted elevated levels of acidity and dissolved oxygen, sufficient to pose a risk to aquatic life, at monitoring stations within the Namozine Creek subwatershed, and the stream was listed as an impaired waterbody, in need of a restoration plan under Section 303(d) of the Clean Water Act.