[11] At the 36th Yokohama Film Festival Seino won a Best Newcomer award for her work in Tokyo Tribe and Danger Dolls.

[12] Later in 2014 Seino turned 20 years old while playing the supporting role of Kanna Seki in the Fuji TV drama Time Taxi.

[13] The next year Seino played the lead role of Ai in Mamoru Oshii's bullying revenge film Nowhere Girl, as well as supporting roles in the TV Tokyo drama Love Theory,[14] the TBS adaptation of the manga series Dr. Storks,[15] the TBS police drama Ouroboros,[16] and the Yoshihiro Nishimura historical film The Ninja War of Torakage.

[20] That same year she starred in the film Perfect Revolution as Mitsu, a mentally ill prostitute who falls in love with a man who has cerebral palsy.

[21] In 2018 Seino appeared as Yuko Komiya in several episodes of the 98th NHK asadora Half Blue Sky,[22] and as Riko Akasaka in NTV's adaptation of the Hiroyuki Nishimori manga series From Today, It's My Turn!!