A former fundraiser for the Democratic Party, she later became founder and CEO of the centrist organization No Labels.

[14][15][16] In 2021, the Problem Solvers Caucus, composed of an equal number of Democrats and Republicans, released a "Building Bridges" blueprint for a bipartisan infrastructure deal.

[17][18] In connection with her work with No Labels, New York Times columnist David Brooks described her in 2016 as an "undeterrable" leader.

[19] Jacobson is married to Mark Penn, President and Managing Partner of The Stagwell Group, former Democratic pollster and executive for Microsoft and Burson-Marsteller.

[20] The couple met in 1996 when Evan Bayh, then governor of Indiana, introduced them at a Democratic Leadership Council event.