[1] Tsiboe was educated at Saltpond Methodist School and Mboforaturo College, where she completed a degree in Teacher Training and Domestic Science.
[1] In 1952, Tsiboe visited the United Kingdom, to attend the conference of the World YWCA and undertake a 12-month course in social services.
[1] Tsiboe stood as Ghana Congress Party (GCP) candidate for Kumasi South Constituency in the 1954 Gold Coast general election.
"[4] Though billed as "the housewife's choice",[5] Tsiboe's uncompromising stance has also been viewed as demonstrating "the extent to which Western education had failed to domesticate women".
[6] The couple's children include John K. Tisoboe, who took over the family printing business,[citation needed] and the fashion designer Nancy Tsiboe, later dubbed 'Miss Africa'.