[4] Comstock made her professional stage debut at the Fourteenth Street Theatre on September 12, 1887, as the telegraph operator in the Charles Hale Hoyt farce A Hole in the Ground.

[4][5][6] In 1891 she toured as Lady May in Mavourreen, an Irish musical written by George Jessop for William J. Scanlan, and on October 31, 1892, Comstock played Valentine at the Standard Theatre in The Family Circle, a Sydney Rosenfeld adaptation of Bisson's Rue Pigalle 115.

That year and over the next several, Comstock appeared in New York and on tour as Sally Sartoris opposite John B. Mason in the Madeline Lucette Ryley comedy The Altar of Friendship; as Martha Ladbrook with Henrietta Crosman in Joan o' the Shoals by Evelyn Greenleaf Sutherland; as Marjorie Leighton with William Collier, Sr. in the Robert Edeson drama The Diplomat; as Ethel Willing, with William Collier, Sr. in Eugene Presbrey's play Personal; as Molly Wood, with Dustin Farnum in The Virginian, an early stage adaptation of the Owen Wister novel; as Lucy, with William Collier, Sr. in The Dictator, a farce by Richard Harding Davis; and starred as Virginia Carvel in an adaptation of the Winston Churchill novel The Crisis.

[4][5] In 1905, Comstock toured as Grace Whitney with Raymond Hitchcock in the Richard Harding Davis farce The Galloper, and the following year appeared in the play’s January 6 New York debut at the Garden Theatre.

The following year, she co-starred with Robert C. Hilliard as The Mother in a long run of the Porter Emerson Browne tale A Fool There Was from the Rudyard Kipling poem The Vampiers.

[9] In December 1912, with the National Federation of Theatre Clubs, Comstock appeared at the Berkeley Lyceum, New York, as Gertrude in the Ethelyn Emery Keays play His Wife By His Side.