[7] Lackaye's professional acting debut occurred in 1883 when he portrayed Lucentio in Francesca da Rimini at the Star Theatre in New York.

[9] Lackaye toured in vaudeville during World War I, performing in the one-act plays Quits and The Bomb.

[9] He married three times: first to actress Annie Lewis,[10][11] second to Alice Evans and lastly to Katherine Alberta Riley.

[8][12] Lackaye died of an acute heart attack at age 69 at his home in New York City.

[5] His funeral was held in St. Malachy's Roman Catholic Church, and he was buried in Calvary Cemetery.