Nang Mwe San became a trained physician at the age of 22 and subsequently worked as a medical officer for local hospitals and NGOs in Shan, Kachin, and Rakhine States, including in displaced camps for the Rohingya Muslims.
[3] Mwe San initiated posting sexually charged photos of swimwear and lingerie on social media as a hobby, garnering an audience and leading to commercial appearances.
[13][14][15][16] Highlighting the distinction between her work as a sexy model and traditional pornography has played a role in mitigating the stigma associated with her career choice in a country where little differentiation is made between the two.
In the aftermath of the 2021 Myanmar coup d'état, she actively engaged in the anti-coup movement, participating in person at rallies and leveraging her social media presence with 2.2 million followers.
Nang Mwe San joined the "We Want Justice" three-finger salute movement, which originated on social media and has garnered support from numerous celebrities.
[20][21] She has been a vocal critic of the country's military coup, expressing her views through videos and actively participating in protests alongside the people, including in front of the Embassy of the United States, Yangon.
[24] In a media interview, Nang Mwe San announced her retirement as a sexy model, stating, "I have to go back to being a doctor to make my father proud.
"[25] On 5 August 2022, the military junta initiated a legal case against Nang Mwe San and another popular sexy model, Thinzar Wint Kyaw.
As per an announcement by the state-controlled media MRTV, they have been arrested and detained under Section 33(a) of the Electronic Law for earning money by posting sexually revealing photos on the websites OnlyFans and Extrania.