She married Bagyidaw when he was Prince of Sagaing, then became chief queen consort when he ascended to the throne on 5 June 1819, gaining the title Namadaw Mibaya Khaunggyi (lit.

She was the great-granddaughter of the hero Bala Thaman, who founded the village Palangon and was assigned to the local fort to help guard against the Manipuris during the reign of King Mahadhammaraza Dipadi of the Nyaungyan dynasty.

According to historian Hmawbi Saya Thein, it is believed that U Hlote had three children: Me Pu, Maung O, and Me Nu.

During the reign of King Bodawpaya, a falcon took 11-year-old Me Nu's sarong as she was bathing, dropping the garment in the left wing of the southern royal palace.

This granted her the rights to nine villages (five of them salt farms), thirty horses, 3,000 pei of land, and the taxes from four kinds of products.

[3] Prince Sagaing became the seventh king of the Konbaung dynasty, on 7 June 1819, making Me Nu his chief queen and given the title of Thiri Pavara Mahayazeinda Yadana Dewi.

Her husband also given the title of "Thadoe Minhla Kyawhtin" and granted the appanage of Salin to her brother, Maung O.

[4] General Maha Bandula died in Danubyu, and the British troops occupied the Yandabo, 40 miles from the royal capital.

After the disastrous First Anglo-Burmese War (1824–1826) left the country crippled, Bagyidaw became increasingly reclusive, afflicted by bouts of depression and could not handle the administration of the state.

Me Nu and Maung O became the de facto rulers of the country, and they were much feared due to their tyrannical policies.