Nanticoke is a town in Broome County, New York, United States.

The town is on the western border of the county and is northwest of Binghamton.

The two villages, Glen Aubrey and Nanticoke, grew up around flour and lumber mills.

Nanticoke Creek flows southward from the town to the Susquehanna River.

17.6% of all households were made up of individuals, and 7.0% had someone living alone who was 65 years of age or older.