Yamamoto is also the only driver to have won both the Super Formula and GT500 championships in the same season multiple times, a feat which he accomplished in 2018 and 2020.

Ahead of the 2018 season, 2009 Formula One world champion Jenson Button joined Team Kunimitsu as Yamamoto's co-driver.

[6] He was in position to win his third GT500 title in four years at the final race at Fuji, but was taken out of contention after being hit by GT300 class Honda driver Ren Sato.

They ended the year with a win at Motegi from pole position, as Yamamoto finished third in the championship for the second consecutive season.

After the race, Yamamoto, Makino, and team principal Kazuhiro Kojima carried a portrait of Takahashi with them to the post-race interviews.

However, the championship tiebreaker in Super Formula at the time went to the driver that scored the most points at the last race meeting of the season at Suzuka.

After the introduction of the new Dallara SF14 in 2014, Yamamoto took five pole positions, four podiums and two wins (both at Suzuka) from 2014 to 2017, and was the leading Honda driver in the standings in 2014 and 2015.

He won his second championship in 2018, with three wins on the season including the first and last rounds at Suzuka, the latter of which clinched his second title ahead of Nick Cassidy.

He won the championship for the third time in 2020, by just two points over Ryo Hirakawa (whom he had also defeated to win the GT500 title earlier that year).

For the first time since 2014, Yamamoto failed to win a race or record a podium finish, slumping to a career-worst 13th place in the championship.

Yamamoto's winless drought came to an end during the seventh round of the championship at Motegi when he won a wet race from pole position.

[14] Yamamoto would get his first chance to drive a Formula One car in 2019, when he drove for Scuderia Toro Rosso-Honda in the first practice session of the Japanese Grand Prix.

[15][16] This participation made him the first Japanese driver to drive during a Formula One Grand Prix session since Kamui Kobayashi in 2014.