She was born in Oldham, Lancashire to Albert Radcliffe—a Canon of Manchester Cathedral—and Petrina, a teacher.
[1][2] She was educated at The Blue Coat School in Oldham and the Royal Welsh College of Music and Drama, having not been accepted on her first attempt.
Early television appearances include major roles in Kay Mellor's Band of Gold and Russell T Davies's The Grand, before she took the role of Alison Wakefield in the Granada Television soap opera Coronation Street.
When her contract was not renewed, the character was written out in a scene that saw her commit suicide by jumping in front of a lorry.
The scene, watched by 17 million viewers, won Radcliffe the British Soap Award for Best Exit.