He joined the party in which his uncle K. N. Nehru was already a member and at that time the Public Welfare Minister of the state government.

Subsequently, Napoleon nurtured the Perambalur constituency in the hope of becoming a member of parliament for the DMK and succeeded in the 2009 Lok Sabha election.

Later after years into film industry, he also got the chance to work as a supporting actor in popular movies such as Pokkiri (2007) and Dasavathaaram (2008).

[10] Though he settled in Nashville, Tennessee, United States of America, at the insistence of the industry stalwarts, he made his acting comeback with Kidaari (2016).

[11][12] After making his Hollywood debut in the supernatural thriller, Devil's Night: Dawn of the Nain Rouge (2019), he was seen in another American independent film titled Christmas Coupon (2019).

[13] Nepoleon Duraisamy forayed into IT Entrepreneurship and kick started "Jeevan Technologies" IT operations in Chennai, India in the year 2000.

[14] In 2010, Napoleon established Myopathy Unit of Jeevan Foundation, the Institute for Muscular Dystrophy & Research Center.