The rebuke became a standout moment in New Hampshire primary history; the remark was wildly cheered by the audience and even applauded by most of Reagan's opponents.

Alex Chen, valedictorian of the class of 2009, wrote to all the candidates running in both the Democratic and Republican primaries and invited them to come to the school to speak.

[citation needed] Most of the primary candidates, including Hillary Clinton, Barack Obama, John McCain and Ron Paul, accepted his invitation.

In 2008, after his defeat in the New Hampshire Democratic primary, Barack Obama gave his famous "Yes We Can" speech in the school's gym.

Nashua High School South offers students the opportunity to participate in various sports teams through its athletic program.

The school fields teams in sports such as football, basketball, baseball, softball, soccer, volleyball, and wrestling.

On January 6, 2020, Nashua High School South underwent a renovation and upgrade of its weight room in honor of former student Nathaniel Tejeda, also known as "Smiley."

[9] Subjects at Nashua High School South are divided into eight departments: English, Social Studies, Information and Computer Technology, Science, Mathematics, Health, Physical Education, and Fine Arts.

Before the third and fourth blocks start, students are given a recess period known as "E-Block" to study or participate in school clubs.