The clubhouse was originally built in 1813-14 as the home of Samuel Miller, the second professor of the Princeton Theological Seminary, on land belonging to his father-in-law, Continental Congressman Jonathan Dickinson Sergeant.

Sergeant had built a large house on the site shortly before the American Revolution but it was burned down during the British occupation prior to the Battle of Princeton.

Originally formed as a men's club, it has allowed both male and female members for several decades.

The clubhouse was expanded in 1911, by architect Aymar Embury II,[4] and in 1969 a banquet dining room was added, with extensive renovations in 1992.

[5] In popular culture, the Nassau Club was referenced in the lyrics of the 1981 hit song The American by Scottish rock group Simple Minds.