[5] Chatzigiannidou's tenure in Filiriakos coincided with the club's golden years; Regional Championship in 1992–93 season and promotion; in addition to the 2000 A Division title, they were also runners-up in 1998, 2001, 2002 and 2004, and third in 1999; the successes include presences in European tournaments such as Women's Cup of Italy (version of Sicily in 2003), which was organized jointly by UEFA and the Italian Football Federation (FIGC), where the club was honoured by the latter, and the International Tournament of Pecquencourt among others,[14] and a 3–0 victorious friendly match against Women's national team for 2005 Prespes Festival on 27 August 2005, where Chatzigiannidou scored the third goal,[15] an era the club provided the national teams with 24 footballers during their 15 years of existence, until 2006,[16] of being herself an international footballer,[12] and also serving the club from the position of the captain.
[19] For the season 2022–23, Chatzigiannidou joined REA,[9][10] the successor club of Asteras Ladies Rethymno.
[20][21] On 2 November 1997, Chatzigiannidou made her debut for Greece women's national football team in a match against Yugoslavia, where she also scored.
[1][11] On 26 January 2016, Chatzigiannidou made her 139th top level international appearance and tied Giorgos Karagounis, in a match against Albania for the UEFA Women's Euro 2017 qualifiers, a feat combined with remarkable stability in the national team, having played in 139 matches out of 146 available since her debut.
[22][4] On 8 March 2016, after making her 140th appearance in a match against Ukraine for the UEFA Women's Euro 2017 qualifiers, Chatzigiannidou surpassed Giorgos Karagounis' previous record, becoming the most capped Greek footballer in the history of the Greece national teams (including both men's and women's), and after the match was awarded a commemorative cap jointly by the Hellenic Football Federation and UEFA for the feat.