She is best known for starring as Elena "Yo-Yo" Rodriguez / Slingshot in the ABC superhero drama series Agents of S.H.I.E.L.D.

This was followed by supporting roles in numerous Spanish-language films, such as Sucedió en un día (2010) and Lluvia de Luna (2011).

She earned her first major leading role in the drama film Ventanas al mar (2012), opposite veteran actors Charo López and Fernando Guillén.

Cordova-Buckley earned her first American acting role in the sports drama film McFarland, USA (2015), opposite Kevin Costner.

[2] She almost quit acting before winning the role of Elena "Yo-Yo" Rodriguez in the ABC superhero drama series Agents of S.H.I.E.L.D.

[6] In 2017, she guest starred as attorney Julia Ramos in the A&E horror drama series Bates Motel, where she worked opposite Vera Farmiga and Freddie Highmore.