She is known for starring as Nancy Wheeler in the Netflix science fiction horror series Stranger Things (2016–present).

She has also appeared in the Peacock comedy thriller series Based on a True Story (2023) and in the films Yes, God, Yes (2019), Velvet Buzzsaw (2019) and Things Heard & Seen (2021).

[9] Dyer began her professional career during her early teenage years, taking part in projects produced in and around her home in Tennessee; her first screen role was as Clarissa Granger in Hannah Montana: The Movie in 2009.

Among her more notable credits are supporting roles in the horror films Velvet Buzzsaw (2019) and Things Heard & Seen (2021).

[18] Since 2016, Dyer has been in a relationship with English actor Charlie Heaton, with whom she co-stars in Stranger Things.